Pharmacy experts discuss their level of confidence with biosimilars and some of the hurdles that stand in the way of optimizing these lower-cost medicines.
Biosimilars have helped to transform the treatment of breast cancer in recent years, given that there are multiple trastuzumab biosimilars now available, according to Jacob Kettle, PharmD, BCOP, who led a recent discussion on the topic for Pharmacy Times®.
Kettle, with the University of Missouri Health Care, Columbia, spoke with Allison Butts, PharmD, BCOP, of the University of Kentucky Markey Cancer Center in Lexington. They discussed payer policy and its influence on choice of biosimilars, along with concerns about use of biosimilars in place of originator drugs.
Open to Using Biosimilars
The Markey Cancer Center has been open to the use of biosimilars, Butts said, indicating that she feels comfortable substituting these products for reference trastuzumab and hasn’t noticed much “pushback” against biosimilars from the clinician community at Markey.
FDA standards for approval give her confidence in biosimilars, although Butts said she pays close attention to infusion reactions. “Infusion reactions are interesting when we’re talking about monoclonal [antibodies] because that’s certainly a concern with any [biosimilars] across the board. Does that rate of infusion reaction change or not?”
Biosimilars are more widely accepted as supportive care drugs, but in the oncology curative setting, there’s nervousness among physicians because the stakes are higher, Kettle noted. He asked Butts whether Markey clinicians experienced the same concerns about using trastuzumab biosimilars in the curative setting.
Butts replied there were no concerns. “They can show that it’s effectively targeting HER2-[positive breast cancer]. It’s effectively clearing out and leaving the body as it’s supposed to,” she said.
Payer Mandates and Choice
For his part, Kettle said that University of Missouri encounters difficulty employing and optimizing biosimilars amid multiple payer mandates that dictate which biosimilars may be used. “We have a lot of different payer mandates in the mix that preclude us from being able to drive the ship to what may be best for our own institution,” he said. “One payer may prefer product A for clinical, operational, and financial reasons—what have you. Another payer may like product B, and another may like product C.
“Half of patients are still on the originator product because they’ve been on it for 5 years, and we don’t want to disrupt them,” he said.
“That creates a nightmare scenario from [the perspective of] ordering, authorizations, and drug dispensing. To me, that is the bigger hurdle that we’ve encountered with biosimilars and how they play a role in cancer therapy,” he said.
University of Missouri Health Care finds these issues a challenge in getting the most out of biosimilars, Kettle said.
“That’s a great point,” Butts said. “You have to draw the line somewhere. You can’t have 10 trastuzumab products sitting in your refrigerator” because each payer requires something different.
Click here to find out how Emory Healthcare in Atlanta, Georgia, succeeded in getting physicians to incorporate use of biosimilars.
AON Saves Over $243 Million With High Biosimilar Adoption
April 22nd 2024Thanks to high biosimilar adoption rates within the community oncology setting, American Oncology Network (AON) saved upwards of $243 million between 2020 and 2023, according to a presentation at the Festival of Biologics USA conference in San Diego, California.
A New Chapter: How 2023 Will Shape the US Biosimilar Space for 2024 and Beyond
December 31st 2023On this episode of Not So Different, Cencora's Brian Biehn and Corey Ford take a look back at major policy and regulatory advancements in 2023 and how these changes will alter the space going forward.
The 6 Key Policy Factors to Ensure Biosimilar Market Sustainability
April 16th 2024Magnus Bodin, senior director and head of international access and policy at Biogen, presented warning signs for unsustainable biosimilar markets as well as key factors needed to create effective policies and future-proof biosimilar markets globally.
What Clinicians Need to Know About Using Biosimilars to Treat IBD
April 13th 2024A review article, intended to act as a guide for clinicians, summarizes the available infliximab and adalimumab biosimilars for treating inflammatory bowel disease (IBD) as well as others that are coming down the pipeline.
Global Biosimilar Market Projected to Reach $1.3 Trillion by 2032
April 11th 2024The global biosimilar market is projected to surge from $25.1 billion in 2022 to approximately $1.3 trillion by 2032, with a compound annual growth rate of 17.6%, driven mainly by the increasing prevalence of cancer and the cost-effectiveness of biosimilars, as outlined in a report by Towards Healthcare.