The Innovation and Value Initiative (IVI) has updated its existing prototype economic model examining value among rheumatoid arthritis (RA) therapies to include biosimilars.
The Innovation and Value Initiative (IVI) has updated its existing prototype economic model examining value among rheumatoid arthritis (RA) therapies to include biosimilars, triple therapy, Janus kinase (JAK) inhibitors, sarilumab, as well as updated treatment effect estimates based on additional randomized controlled trial (RCT) evidence, and updated cost estimates.
The update follows a research brief released last month that questioned whether "conventional head-to-head cost-effectiveness analyses may not align with decision making in chronic disease," citing an analysis of JAK inhibitors for the treatment of rheumatoid arthritis (RA).
The issue of who gets to decide "value" in an era of ever-increasing drug costs has become a point of debate in recent years.
The IVI model, IVI-RA, is intended to help payers and other stakeholders identify high-value therapies by simulating the lifetime costs and benefits of different strategies for treating patients with moderate-to-severe RA. IVI said its latest research highlights the type of additional questions important for patients, providers, and payers that make value assessments; it also incorporates real-world data.
The model is designed to examine a variety of factors with the inclusion of real-world patient data, including:
IVI will continue to update the model in 2020 to include the duration of maintenance treatment and the impact of prior treatment.
“Value assessments must be relevant to real-world decision makers and can be vastly improved by an ability to showcase how real patients experience disease,” says Jennifer Bright, IVI’s executive director, in a statement. “We recognize that our open-source model is just a start, which is why we are calling for partners to work with us, sharing real-world data on outcomes so we can answer even more questions. Our aim is to perfect this model to answer questions truly important to patients, providers, and payers.”
IVI-RA was the first disease-specific economic model developed within IVI’s Open-Source Value Project (OSVP), which serves as a laboratory for developing next-generation economic models in an open-source environment. The model was initially released in November 2017.
The Trump Administration’s Drug Price Actions and Why US Prices Are Already Sky-High
May 17th 2025While the Trump administration’s latest executive order touts sweeping drug price cuts through international benchmarking, the broader pharmaceutical pricing crisis in the US reveals a far more complex web of development costs, profit incentives, and absent price controls—raising the question of whether any single policy, including potential drug tariffs, can truly untangle it.
Escaping the Void: All Things Biosimilars With Craig & G
May 4th 2025To close out the Festival of Biologics, Craig Burton and Giuseppe Randazzo from the Association for Accessible Medicines and the Biosimilars Council tackle the current biosimilar landscape and how the industry can emerge from the "biosimilar void."
How AI Can Help Address Cost-Related Nonadherence to Biologic, Biosimilar Treatment
March 9th 2025Despite saving billions, biosimilars still account for only a small share of the biologics market—what's standing in the way of broader adoption and how can artificial intelligence (AI) help change that?
Biosimilar Market Development Requires Strategic Flexibility and Global Partnerships
April 29th 2025Thriving in the evolving biosimilar market demands bold collaboration, early global partnerships, and a fresh approach to development strategies to overcome uncertainty and drive future success.