- Bone Health
- Immunology
- Hematology
- Respiratory
- Dermatology
- Diabetes
- Gastroenterology
- Neurology
- Oncology
- Ophthalmology
- Rare Disease
- Rheumatology
Research Finds Biosimilar Filgrastim as Efficient as Its Reference in PBSC Mobilization
A recent study, published in Transfusion, analyzed 3 granulocyte-colony-stimulating factor treatments in an attempt to compare the mobilization efficiency of 2 innovator G-CSF treatments with that of 1 biosimilar treatment.
In patients with multiple myeloma (MM) who are eligible for autologous blood stem cell transplantation, high-dose chemotherapy followed by transplantation is standard first-line therapy. After a patient receives 3 to 4 cycles of induction therapy, 1 cycle of mobilization-specific chemotherapy is typically followed by the administration of a granulocyte-colony-stimulating factor (G-CSF) treatment to facilitate the mobilization of peripheral blood stem cells (PBSCs) prior to collection.
A recent study, published in Transfusion, analyzed 3 G-CSF treatments in an attempt to compare the mobilization efficiency of 2 innovator G-CSF treatments with that of 1 biosimilar treatment.
The retrospective study compared the mobilization efficiency of reference filgrastim (Neupogen), lenograstim (Granocyte), and biosimilar filgrastim (Filgrastim Hexal) in a homogeneous group of 250 patients with MM in first-line treatment. Of this group, 30% (n = 73) received the reference filgrastim, 52% (n = 131) received biosimilar filgrastim, and 18% (n = 45) received lenograstim. Each patient received a subcutaneous dose of 5 to 10 µg per kilogram of body weight beginning at day 5 after chemomobilization until the collection of CD34-positive (CD34+) cells was complete.
The study found that there were no significant differences in mobilization of CD34+ cells or in collection yields among the reference filgrastim group (median: 10 CD34+ cells × 106/kg body weight; range: 2.7 to 40.4), the biosimilar filgrastim group (median: 9.9; range: 0.2 to 26.0) and the lenograsim group (median 10.7; range: 3.1 to 27.9). Overall, 249 of the 250 patients reached the collection goal of 2 × 106 CD34+ cells per kilogram of body weight during a median of 1 (range: 1 to 3) collection session.
The researchers concluded that there were no significant differences in PBSC mobilization or in reaching individual collection targets among innovator treatments and the biosimilar treatment in patients with MM.
Similar Persistence Rates Between Adalimumab New Starts, Switched Patients
December 7th 2024A French real-world study found that the adalimumab biosimilar SB5 was effective in treating rheumatic or gastrointestinal immune-mediated inflammatory diseases, showing no loss of disease control in switched patients and similar persistence rates between naive and switched groups.
Biosimilars Gastroenterology Roundup for November 2024—Podcast Edition
December 1st 2024On this episode of Not So Different, we discuss market changes in the adalimumab space; calls for PBM transparency and biosimilar access reforms grew; new data for biosimilars in gastroenterology conditions; and all the takeaways from this year's Global Biosimilars Week.
Commercial Payer Coverage of Biosimilars: Market Share, Pricing, and Policy Shifts
December 4th 2024Researchers observe significant shifts in payer preferences for originator vs biosimilar products from 2017 to 2022, revealing growing payer interest in multiple product options, alongside the increasing market share of biosimilars, which contributed to notable reductions in both average sales prices and wholesale acquisition costs.
Biosimilars Development Roundup for October 2024—Podcast Edition
November 3rd 2024On this episode of Not So Different, we discuss the GRx+Biosims conference, which included discussions on data transparency, artificial intelligence (AI), and collaboration to enhance the global supply chain for biosimilars and generic drugs, as well as the evolving requirements for biosimilar devices.
Perceptions of Biosimilar Switching Among Veterans With IBD
December 2nd 2024Veterans with inflammatory bowel disease (IBD) prioritize shared decision-making, transparency, and individualized care in biosimilar switching, favoring delayed switching for severe cases and greater patient control.
