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Laura Joszt, MA, is the vice president of content for the managed care and pharmacy brands at MJH Life Sciences

. She has been with MJH Life Sciences since 2011.

Laura has an MA in business and economic reporting from New York University.

Juliana M. Reed, MS, of the Biosimilars Forum says reference biologics outnumber biosimilars 2:1 in Medicare despite steep discounts.

How Biosimilars Could Lower Part D Costs for Seniors

Brooke McCormick is an assistant editor for 

Juliana M. Reed, MS, of the Biosimilars Forum says employers must watch what replaces rebates under CAA 2026 PBM reforms.

Will PBM Rebate Reform Help Biosimilars Win Formulary Spots?

Skylar Jeremias is the Managing Editor for The Center for Biosimilars and The American Journal of Managed Care (AJMC).

Articles

A commentary on Irish oncology spending finds hospital drug costs rose more than 3100% in under a decade, while biosimilar uptake remained low.

Irish Oncology Drug Costs Rose Over 3100% as Biosimilar Uptake Lagged

Panelists at an IGBA Global Biosimilars Week webinar detailed worldwide access gains and adoption barriers.

IGBA's Global Biosimilars Week Panel Spotlights Value of Access

The Center for Biosimilars connects professionals with insights on biosimilars, health economics, regulatory outcomes, and emerging treatment paradigms.

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Business & Practice

Explore the evolving biosimilars landscape with expert insights on development, regulation, and global health harmonization in this engaging podcast episode.

Follow the Science: Bridging the Biosimilar Gap With Dr Hillel Cohen

In this insightful podcast episode, host Giuseppe Randazzo, senior vice president of sciences and regulatory affairs at the Association for Accessible Medicines (AAM), welcomes former Sandoz executive and biosimilar expert Hillel Cohen, PhD, to discuss the evolving world of biosimilars. The conversation covers the scientific and regulatory landscape, touching on the progress in streamlining biosimilar development, the importance of following scientific advancements, and the potential for harmonization in global health regulations.

This special vodcast series provided by The Center for Biosimilars

 was developed in partnership with the AAM and Biosimilars Council. Check out 

 of the series featuring a discussion between Giuseppe Randazzo and Craig Burton, former executive director of the Biosimilars Council and current senior vice president of government affairs and policy at Fresenius Kabi.



Jeremias S. The Biosimilar Void: 90% of Biologics Coming Off Patent Will Lack Biosimilars. February 5, 2025. Accessed May 3, 2025. 

https://www.centerforbiosimilars.com/view/the-biosimilar-void-90-of-biologics-coming-off-patent-will-lack-biosimilars

Escaping the Void: All Things Biosimilars With Craig & G

Co-hosts Craig Burton, executive director of the Biosimilars Council, and Giuseppe Randazzo, senior vice president of sciences and regulatory affairs at the Association for Accessible Medicines (AAM), tackle the current biosimilar landscape and how the industry can emerge from the "biosimilar void."

 was developed in partnership with the AAM and Biosimilars Council.

By Ashley Henyan, MA, MFA, director of communications at AAM

Since the passing of the Biologics Price Competition and Innovation Act in 2010, the FDA has approved over 70 biosimilar medicines. Since their entry to market in 2015, biosimilars have generated $36 billion in savings for America's patients and the US health care system. Biosimilars have proven they can unlock access to safe, effective, and more affordable treatments. But unfortunately, a dangerous trend threatens to halt progress related to biosimilar uptake and patient access. 

In February 2025, an analysis from the IQVIA Institute revealed a massive biosimilar void.

 A staggering 90% of biologic drugs losing patent exclusivity over the next 10 years have no biosimilar competition in the pipeline. This data underscores a flawed system that limits patient access and negatively impacts the livelihood of millions of Americans. 

However, when it comes to biosimilars, we have the tools to fix the problem. With the right focus, collaboration, and reforms, we can ensure biosimilars continue to bring value to patients, providers, and the broader health care system. 

With thanks to The Center for Biosimilars, this podcast series explores the current biosimilars landscape, dives into urgent actions needed from policymakers and regulators, and offers real-world insights into what changes are needed now to ensure the sustainability of the industry. 

1. Jeremias S. The Biosimilar Void: 90% of Biologics Coming Off Patent Will Lack Biosimilars. February 5, 2025. Accessed May 3, 2025. 

To close out the Festival of Biologics, Craig Burton and Giuseppe Randazzo from the Association for Accessible Medicines and the Biosimilars Council tackle the current biosimilar landscape and how the industry can emerge from the "biosimilar void."

 focuses on the critical issue of cost-related nonadherence in biologic treatments and the role of biosimilars in delivering promised savings. Despite the FDA approving 68 biosimilars, they currently make up only 2% to 3% of the U.S. biologics market, with market share varying significantly between individual markets, ranging from 8% to 82%.

Biosimilars have, however, demonstrated significant cost savings over the past decade. According to data from the Association for Accessible Medicines (AAM), generics and biosimilars collectively saved the U.S. a total of $445 billion by the end of 2023. Biosimilars alone accounted for $12.4 billion in savings in 2023, bringing total savings to $36 billion since their introduction in 2015. Despite these savings, barriers remain, as many biologics set to lose patent exclusivity in the coming years lack biosimilars in development. Addressing cost-related nonadherence and leveraging artificial intelligence (AI) to streamline prescribing processes and increase biosimilar utilization are key topics of discussion.

Josh Canavan, head of pharmacy at RazorMetrics, provides insights into why, despite the substantial savings biosimilars offer, they still represent only 23% of the overall biologics market. The conversation explores how AI-powered tools are assisting physicians in transitioning to biosimilars, enabling patients to access life-saving treatments at a fraction of the cost. As the 10th anniversary of the first biosimilar approval is observed, the discussion highlights the importance of automation, policy reforms, and increased adoption to bridge the affordability gap and expand patient access to these critical treatments.

To learn more about the 10th anniversary of the first FDA biosimilar approval and current insights into the biosimilar industry, 

To learn more about how much biosimilars have saved so far, 

To read more about Josh's views on the pharmaceutical landscape in 2025, 

Despite saving billions, biosimilars still account for only a small share of the biologics market—what's standing in the way of broader adoption and how can artificial intelligence (AI) help change that?

How AI Can Help Address Cost-Related Nonadherence to Biologic, Biosimilar Treatment

This episode of Not So Different explores the possible implications of the Federal Trade Commission's (FTC) second interim report on pharmacy benefit managers (PBMs), which shed light on key issues with current PBM practices and their impact on drug prices. The report highlighted several troubling strategies, such as many cases where the big 3 PBMs were reimbursing their own affiliated pharmacies at higher rates than independent pharmacies. The report's latest findings raise important questions about the future of drug pricing transparency and regulation and challenge the notion of whether PBMs are delivering on their intended promise to benefit the health care system.

To help unpack these findings and their implications, The Center for Biosimilars

 was joined by Joe Wisniewski, an expert in PBM legislation, price transparency, and health care policy. Joe serves as assistant vice president of partnerships and government affairs at Turquoise Health and brings a wealth of insight into how PBMs are navigating the current landscape, especially with the rise of new biosimilars and shifting regulatory pressures.

This episode also explores how a second Trump administration could influence PBM practices, particularly in relation to biosimilars, and what that means for drug pricing efforts moving forward.

To learn more about the FTC's most recent report on PBMs, 

To learn more about the FTC's first report on PBMs, 

To learn more about health care actions taken by the second Trump Administration during it's first month, 

To learn more about the views of Mehmet Oz, MD (more commonly known as Dr. Oz) on price transparency ahead of his congressional confirmation hearings as President Trump's nominee for HHS Secretary, 

On this episode of Not So Different, we explore the Federal Trade Commission’s (FTC) second interim report on pharmacy benefit managers (PBMs) with Joe Wisniewski from Turquoise Health, discussing key issues like preferential reimbursement, drug pricing transparency, biosimilars, shifting regulations, and how a second Trump administration could reshape PBM practices.

Will the FTC Be More PBM-Friendly Under a Second Trump Administration?

On today's episode, we'll dive deep into the US biosimilars market landscape, a topic of growing importance as biosimilars offer significant potential for reducing health care costs and increasing access to life-saving therapies. Understanding the current legislative and regulatory environment is crucial, as it shapes the approval and adoption processes for biosimilars. We'll explore key factors affecting payer uptake and provider adoption of biosimilars in the US, such as economic considerations, clinical evidence, and market dynamics. These factors are vital for stakeholders aiming to effectively navigate the complex biosimilars landscape. Additionally, we'll examine the challenges and opportunities associated with biosimilars for stakeholders across the health care continuum, including manufacturers, payers, providers, and patients. Addressing these challenges and leveraging opportunities can enhance the impact of biosimilars on health care systems and patient outcomes, making this discussion essential for anyone involved in the health care industry.

Today, we're joined by Kyle Noonan, PharmD, MS, is a highly qualified expert who supports scientific and commercial consulting engagements at Cencora, helping manufacturers demonstrate the clinical and economic value of their products. His work includes outcomes research strategy, pre-approval information exchange, payer value proposition development, primary market research, pricing research, and market access strategy.

Dr. Noonan has a diverse background with experience in various health care settings, including medical affairs within the biopharmaceutical industry, association management, consulting, and clinical trial research. He has extensive leadership experience with the Academy of Managed Care Pharmacy (AMCP) and has presented numerous posters at AMCP conferences. Dr. Noonan holds a Doctor of Pharmacy from Mercer University and a Master's in Pharmaceutical Outcomes and Policy from the University of Florida.

To learn more about Cencora and their efforts, 

To learn more about the Inflation Reduction Act's impact on biosimilars, 

Join us as we explore the complexities of the US biosimilars market, discussing legislative influences, payer and provider adoption factors, and strategies to overcome industry challenges with expert insights from Kyle Noonan, PharmD, MS, value & access strategy manager at Cencora.








Biosimilars in America: Overcoming Barriers and Maximizing Impact

In today's episode, we'll be diving deep into the crystal ball, exploring predictions for how advancements from the past year will shape the biosimilar market in 2024 and beyond. With approvals, advancements, and regulatory shifts, the landscape of biosimilars is constantly evolving. And who better to provide us with insights into these changes than our returning guest, Julie Reed, executive director of the Biosimilars Forum?

We'll be delving into the impact of recent developments on market dynamics, discussing how these advancements are reshaping strategies, influencing investment decisions, and ultimately, transforming patient care. From the first on-body pegfilgrastim biosimilar to the growing acceptance of adalimumab biosimilars, we'll dissect the key trends and their implications for the future. But it's not just about looking back; it's about looking forward. Julie will be sharing her predictions for what lies ahead in the biosimilar market. What regulatory challenges can we anticipate? How will market access evolve? And what role will innovation play in driving the next wave of biosimilar adoption?

With Julie's expertise and insights, we'll gain a deeper understanding of the forces shaping the biosimilar landscape and uncover strategies for navigating the opportunities and challenges that lie ahead.

For more information on the Biosimilar User Fee Amendments III (BsUFA III), 

For more information on the 1-year anniversary of adalimumab biosimilars in the US, 

To listen to more of Julie Reed's thoughts on the US biosimilar industry and streamlining development, 

To learn more about the Biosimilars Forum, 

On this episode of Not So Different, Julie Reed, executive director of the Biosimilars Forum, returns to discuss her predictions for the biosimilar industry for 2024 and beyond as well as the impact that the Forum's 4 new members will have on the organization's mission.

Exploring the Biosimilar Horizon: Julie Reed's Predictions for 2024

On this episode, we discuss the biggest news to come out of October 2023, including 3 regulatory approvals, 2 complete response letters, and new data and industry insights that have the potential to impact the entire US biosimilar industry.

FDA Approves First Subcutaneous Infliximab Product

Abrilada Approved as Second Interchangeable Humira Biosimilar

Eye on Pharma: New GI Data and Byooviz Interchangeability Propel Biosimilars Into the Future

Biosimilars Check-In: BI Launches Unbranded Adalimumab; New Omalizumab Deal; CRL for Insulin Aspart

Eye on Pharma: Another CRL for Alvotech; Cimerli’s Growing Market Share; BBCIC Awarded Grant

Samsung Bioepis Presents Positive Phase 3 Data on Aflibercept Candidate

AMCP Nexus: Panelists Share Current Scope of Biosimilar Industry

Biosimilar Business Roundup for October 2023—Podcast Edition

On this episode, we’re going to be giving an overview of some of the biggest stories in the business space regarding biosimilars, like the approval of the first neurology biosimilar, growth projections from company quarterly expense reports, and some analyses about the health of the market.

Stelara and Enbrel Chosen for IRA Price Negotiation

Biocon Biosimilar Quarterly Sales Up 106%

STADA Earnings Project Record Breaking Profits for 2023

Despite Global Increase in Amjevita Sales, US Sales Dropped 63%

Authors Suggest Major Policy Shifts to Boost Biosimilar Development, Accessibility

Cardinal Health Exec: How Adalimumab Biosimilars Can Reshape the US Health Care Industry

On this episode, we’re giving an overview of some of the biggest stories in the business space regarding biosimilars, like the approval of the first neurology biosimilar, growth projections from company quarterly expense reports, and some analyses about the health of the market.

Biosimilars Business Roundup For August 2023—Podcast Edition

With US' market experience with biosimilars approaching a decade, industry experts are beginning to look into ways to accelerate biosimilar development to make more lower-cost products available to patients quicker. Strict regulatory guidelines require manufacturers to conduct numerous expensive and time-consuming preclinical and clinical trials to obtain approval and prove that biosimilars are safe and effective. However, research has shown that not all of these tests may be necessary anymore and there's might be ways to cut down on development spend without compromising safety.

A commentary paper written by 4 representatives from pharmaceutical companies sought to provide an unbiased perspective on this objective can be achieved, noting that extensive testing was needed when biosimilars were new but approval requirements should be updated as the industry gains new information.

Today, I'm joined by Julie Reed, executive director of the Biosimilars Forum, a nonprofit organization aimed at the advancement of biosimilar adoption through collaboration with biosimilar manufacturers. The companies that the paper's authors represent (Samsung Bioepis, Sandoz, Boehringer Ingelheim, and Fresenius Kabi) are all members of the Forum and our discussion with Reed will highlight some of the major pieces from the paper and next steps for the industry to propel biosimilar development into the future.

To register for the FDA's workshop on streamlining biosimilar development, 

To learn more about the Biosimilars Forum and its members, 

To read the IQVIA report cited in the paper, 

On this episode of Not So Different, Julie Reed, executive director of the Biosimilars Forum, expanded on ways to make biosimilar development faster and cheaper without compromising on safety and efficacy and how these practices can ensure a sustainable market for the future.

How Streamlining Development Can Save the US Biosimilar Industry

On this episode, we’re going to be recapping some of the biggest stories in the business space regarding biosimilars, including adalimumab preparation, partnerships for commercialization, and more.

Mark Cuban’s Online Pharmacy Partners With Coherus Biosciences for Humira Biosimilar

Roundup: Coherus Resolves AbbVie Dispute; Bio-Thera Solutions and Celltrion Expand Respective Partnerships

Eye on Pharma: First PBM to Cover Yusimry; Celltrion to Test Ocrevus Biosimilar; Another Stelara Settlement

The Age of Adalimumab Is Upon Us: How Stakeholders Can Prepare

Alvotech, Advanz Pharma Extend Partnership for Biosimilars in Europe

Medicare 340B Program May Be Reducing Biosimilar Uptake

Sandoz Roadmap Aims to Increase Worldwide Biosimilar Adoption by 2030

Biosimilars Business Roundup for June 2023—Podcast Edition

The Association for Accessible Medicines report, prepared with the IQVIA Institute, also reports $25.4 billion in biosimilar savings for the year.

Generic, Biosimilar Medicines Saved US Health Care $496B in 2025

A study found no direct trial evidence for natalizumab or its biosimilar in MS and found limited cost-effectiveness vs most alternatives.

Natalizumab Biosimilar Shows Limited Cost-Effectiveness in MS

Biosimilar denosumab cleared a $150,000 per QALY cost-effectiveness threshold against bisphosphonates for high-risk PMO, but not always at $100,000.

Biosimilar Denosumab Shows Cost-Effectiveness Over Bisphosphonates in PMO

With Medicare open enrollment running through December 7 and the Part D annual 

 rising from $2,100 in 2026 to $2,400 in 2027, seniors and Part D plans are looking for ways to rein in drug costs.

 Biosimilars could be one of them, but beneficiaries still face barriers to accessing these lower-cost products.

Understanding why seniors are not accessing biosimilars is the first step, Juliana Reed, MS, executive director of the Biosimilars Forum, said in an interview with 

"Biosimilars can increase the cost savings and increase the access for seniors," she said.

In both Medicare Part D and Part B, Reed said, reference products outnumber biosimilars in what is offered to beneficiaries by a 2:1 ratio.

"So for every 2 brand drugs, there's 1 biosimilar," she said. PBMs, plans, and CMS are using more reference biologics than biosimilars, she added.

That imbalance persists even as biosimilars launch at steep discounts. Biosimilars referencing 

 (ustekinumab), for example, launched at discounts of 80% to 90%.

 With premiums going up and affordability of health care decreasing for patients and families, Reed said, those savings matter.

"Here we have this incredible biosimilar product that is, again, highly discounted," she said. "But Medicare, especially CMS, is not giving it access."

Reed said CMS has long declined to interfere with PBMs' formulary decisions. She also pointed to Medicare Part B payment rules based on average sales price (ASP), which she said were written before PBMs operated the way they do today.

"Medicare has an opportunity to lower the cost for biologics and for the Medicare beneficiaries who need biologics. But they're not taking any steps forward to make that happen," Reed said.

Changing that will take action from Congress and the administration, she said.

"It's time. There's a lot of us baby boomers going into Medicare, and you don't want to pay for us, and you shouldn't," Reed said. "So, we need to change this."

1. CMS hikes Medicare Advantage rate 2.48% for 2027: 6 notes. Becker's Hospital Review. April 2026. Accessed November 6, 2026. 

https://www.beckershospitalreview.com/finance/cms-hikes-medicare-advantage-rate-2-48-for-2027-6-notes/

2. McCrear S, Reed JM. How the Biosimilars Access and Affordability Act redefines IRA delays. CFB. November 3, 2026. Accessed November 6, 2026. 

https://www.centerforbiosimilars.com/view/how-the-biosimilars-access-and-affordability-act-redefines-ira-delays

Juliana Reed, MS, of the Biosimilars Forum says employers must watch what replaces rebates under CAA 2026 PBM reforms.

 in the Consolidated Appropriations Act 2026 (CAA 2026) will require 100% of manufacturer rebates to be passed through to employer-sponsored plans and, beginning in January 2028, will limit PBM compensation in Medicare Part D to flat service fees that are not tied to drug prices.

 Whether those changes help lower-cost biosimilars win formulary spots may depend on what PBMs do next.

Rebate pass-through and transparency are only one step toward supporting biosimilar uptake, and employers should watch for what replaces rebates, Juliana M. Reed, MS, executive director of the Biosimilars Forum, said in an interview with 

“I think what we have to watch for—and this is where it's important for employers to require transparency—is what replaces rebates,” she said. “Are there new fees? Are there new things that the PBM can implement to continue to have the same amount of revenues coming in because they control access?”

The favoring of higher-cost drugs, whether through PBM rebates or under Medicare Part B in the physician office setting, is a problem the country needs to solve by taking away the mechanisms that allow it, Reed noted. Employers, she said, should be asking for and demanding transparency.

“We have lower-cost biosimilars out there,” Reed said. “We're not favored in any setting where it requires a high rebate, and that is not why biosimilar developers made this commitment, all this incredible amount of money and time to develop biosimilars. We did it to bring lower-cost products.”

Developing a biosimilar can take up to 9 years and cost up to $300 million.

 aimed at supporting that investment, including the Biosimilars Access and Affordability Act, which would automatically delay 

 for a reference biologic when a biosimilar launch is expected.

In theory, rebate pass-through should lower costs and support biosimilar uptake, Reed said. She pointed to the role PBMs played roughly 40 years ago in helping build the small-molecule generic industry.

“Should the PBMs be supporting competition through biosimilars? Yes,” Reed said. “If rebate pass-through and transparency work, that's great. But if something else comes forward that the PBMs put in place to continue to have their revenues…if it blocks access to lower-cost biosimilars, it's not working.”

1. Holland K. Federal PBM compensation shifts: early CAA 2026 considerations. 

. 2026;32(9):In Press. doi:10.37765/ajmc.2026.90007 

https://www.ajmc.com/view/federal-pbm-compensation-shifts-early-caa-2026-considerations

2. McCrear S. Biosimilar bills would automate Medicare negotiation delays. CFB. October 12, 2026. Accessed November 6, 2026. 

https://www.centerforbiosimilars.com/view/biosimilar-bills-would-automate-medicare-negotiation-delays

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