Jackie Syrop

Study Finds ABP 215 and Bevacizumab Demonstrate PK Similarity in Japanese Men

November 18, 2018

The researchers say that their data were consistent with the pharmacokinetic equivalence previously demonstrated in a single-dose PK study that included 202 healthy adult men in the United States and European Union, and thus add to the evidence of ABP-215 as a high-quality biosimilar to bevacizumab for use in Japan.

Research Underscores Rituximab's Utility in Treating MS

November 15, 2018

Rituximab is frequently used off-label as a treatment for relapsing-remitting multiple sclerosis (MS) because it induces the depletion of circulating B-cell and T-cell lymphocytes and targets CD20 protein in B cells that are responsible for the production of antibodies.

Does Biosimilar Infliximab Have a Role After Secondary Loss of Response to Its Reference?

November 15, 2018

Results of a small Greek observational study suggest that biosimilar infliximab may be an effective alternative for the treatment of patients with inflammatory bowel disease (IBD) who have active disease and experienced a loss of response to innovator infliximab (Remicade).

US Drug Prescription Rates Influenced by Race, State Healthcare Laws, and Wealth

November 14, 2018

The best predictors of which US counties’ patients are most likely to be prescribed higher-priced drugs are income, healthcare costs, and access to exercise opportunities, according to a new study published online in Nature Communications.

First-Line Bevacizumab More Effective in MBC Not Previously Treated with Taxanes

November 14, 2018

Among long-term responders, first-line bevacizumab-based therapy is more effective in patients with HER2-negative metastatic breast cancer (MBC) who were not previously treated with taxanes, a recent Spanish study suggests.

Patients With CLL Who Have Anaphylaxis With Obinutuzumab May Be Able to Receive Rituximab

September 16, 2018

Rituximab-based immunochemotherapy can be safely applied in patients after obinutuzumab-associated anaphylaxis, but the existing risk of cross­reactivity should be considered, and careful monitoring of such patients during rituximab infusion is required.

Review Urges Better Guidelines for Optimal Management of Patients With Crohn Disease

September 14, 2018

Up to 60% of Crohn disease patients taking an anti—tumor necrosis factor (TNF) monoclonal antibody medication eventually stop responding to treatment, but the optimal management of these patients has not been clearly defined.

Study Suggests Predictive Biomarker for Therapeutic Outcomes in Ankylosing Spondylitis

September 14, 2018

A new study suggests that CD8+ natural killer cells are a biomarker that can predict therapeutic outcome for patients with ankylosing spondylitis who are administered anti–tumor necrosis factor agents because they are nonresponsive to conventional treatment.